Is It Type 2 Inflammation?

IT'S TIME TO FEEL MORE LIKE YOURSELF

IS IT TYPE 2 INFLAMMATION?

It’s time to tell the world, “This is who I really am.” Take the first step by finding out if type 2 inflammation could be the underlying cause of your disease.

Stories of Who I Am

Hear from people around the world with type 2 inflammation and discover how new knowledge is helping them live their lives to the fullest.

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Connected Diseases

Type 2 inflammatory diseases may be different, but the experiences and challenges are often shared. These connections not only bring people together—they can help you better understand your disease.

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REFERENCES

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³Cherwinski, H. M., Schumacher, J. H., Brown, K. D., & Mosmann, T. R. (1987). Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. The Journal of experimental medicine, 166(5), 1229-1244

⁴Snapper CM, Finkelman FD, Paul WE. Regulatiopn of IgG1 and IgE production by interleukin 4. Immunological reviews. 1988 Apr 1;102(1):51-75.

⁵Mosmann, T. R. & Coffman, R. L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).

⁶Ray, Anuradha, Timothy B. Oriss, and Sally E. Wenzel. “Emerging molecular phenotypes of asthma.” American Journal of Physiology-Lung Cellular and Molecular Physiology 308.2 (2015): L130-L140.

⁷Muraro, Antonella, et al. “Precision medicine in patients with allergic diseases: airway diseas and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology.” Journal of allergy and clinical immunology 137.5 (2016): 1347-1358.

⁸Matsusaka, Masako, et al. “Subphenotypes of type 2 severe asthma in adults.” The Journal of Allergy and Clinical Immunology: In Practice 6.1 (2018): 274-276.

⁹Khan, Asif et al. “Type 2 inflammation-related comorbidities among patients with asthma, chronic rhinosinusitis with nasal polyps, and atopic dermatitis.” European Respiratory Journal 2020; 56: Suppl. 64, 232.

¹⁰Silverberg, Jonathan I. Comorbidities and the impact of atopic dermatitis. Annals of Allergy, Asthma & Immunology. 2019.

¹¹Bieber T. Mechanisms of disease: atopic dermatitis. N Engl J Med. 2008; 358:1483-9.

¹²Gittler, J. K. et al. (2012). Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis. The Journal of allergy and clinical immunology, 130(6), 1344-1354.

¹³Bjermer L. Time for a paradigm shift in asthma treatment: from relieving bronchospasm to controlling systemic inflammation. Journal of Allergy and clinical Immunology. 2007 Dec 1;120(6):1269-75.

¹⁴Fokkens WJ, Lund VJ, Hopkins C, Hellings PW, Kern R, Reitsma S, Toppila-Salmi S, Bernal-Sprekelsen M, Mullol J, Alobid I, Anselmo-Lima WT. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;58:I-+.

¹⁵Huang E, Ong PY. Severe atopic dermatitis in children. Current allergy and asthma reports. 2018 Jun;18(6):1-8.

¹⁶von Mutius E. The burden of childhood asthma. Archives of disease in childhood. 2000; 82(suppl 2):ii2-ii5.

¹⁷Menard-Katcher P, Marks KL, Liacouras CA, Spergel JM, Yang YX, Falk GW. The natural history of eosinophilic oesophagitis in the transition from childhood to adulthood. Alimentary pharmacology & therapeutics. 2013
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¹⁸Zuberbier T, Orlow SJ, Paller AS, et al. Patient perspectives on the management of atopic dermatitis. J Allergy Clin Immunol. 2006;118(1):226-232.

¹⁹Sanz de Burgoa V, Rejas J, Ojeda P. Self-perceived sleep quality and quantity in adult subjects with asthma: Findings from the CosteAsma study. J Investig Allergol Clin Immunol. 2016;25(4).

²⁰Lucendo AJ, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-358.

²¹Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. 2022. Available at:
https://ginasthma.org/gina-reports/ . Accessed: July 2022

²²Sidbury R, Tom WL, Bergman JN, Cooper KD, Silverman RA, Berger TG, Chamlin SL, Cohen DE, Cordoro KM, Davis DM, Feldman SR. Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches. Journal of the American Academy of Dermatology. 2014 Dec 1;71(6):1218-33.

²³European Respiratory Society. European Lung White Book, Chapter 2: The economic burden of lung disease. Available at: https://www.ershwhitebook.org/chapters/the-economic-burden-of-lung-disease/ . Accessed: June 2021.

²⁴Eckert L, Gupta S, Gadkari A, Mahajan P, Gelfand JM. Burden of illness in adults with atopic dermatitis: Analysis of National Health and Welness Survey data from France, Germany, Italy, Spain, and the United Kingdom. J Am Acad Dermatol. 2019;81(1):187-195.

²⁵Mukkada V, et al. Health-Related Quality of Life and Costs Associated With Eosinophilic Esophagitis: A Systematic Review. Clin Gastroenterol Hepatol. 2018;16(4):]495-503.

²⁶Milton B et al. The social and economic consequences of childhood asthma across the lifecourse: a systematic review. Child: care, health and development. 2004 Nov;30(6):711-28.

²⁷Daugherty, Jonas, et al. “The impact of long-term systemic glucocorticoid use in severe asthma: a UK retrospective cohort analysis.” Journal of Asthma 55.6 (2018): 651-658.

²⁸Hirano I, Chan ES, Rank MA, Sharaf RN, Stollman NH, Stukus DR, Wang K, Greenhawt M, Falck-Ytter YT, Chachu KA, Day L. AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Gastroenterology. 2020 May 1;158(6):1776-86.

²⁹Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, Chamlin SL, Cooper KD, Feldman SR, Hanifin JM, Krol A. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. Journal of the American Academy of Dermatology. 2014 Aug 1;71(2):327-49.

³⁰Menzies-Gow A, Canonica GW, Winders TA, de Sousa JC, Upham JW, Fink-Wagner AH. A charter to improve patient care in severe asthma. Advances in therapy. 2018 Oct;35(10):1485-96.

³¹Staikuniene J, et al. Association of chronic rhinosinusitis with nasal polyps and asthma: clinical and radiological features, allergy and inflammation markers. Medicina (Kaunas) 2008; 44(4):257-265.

³²Liu, Jing Nan, et al. The prevalence of serum specific IgE to superantigens in asthma and allergic rhinitis patients. Allergy, Asthma & Immunology Research. 2014;6(3):263-266.

³³Schleimer, Robert P., and Sergejs Berdnikovs. Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases. Journal of Allergy and Clinical Immunology. 2017;139(6):1752-1761.

³⁴Sugita K, Kabashima K. Tight junctions in the development of asthma, chronic rhinosinusitis, atopic dermatitis, eosinophilic esophagitis, and inflammatory bowel diseases. Journal of leukocyte biology. 2020 May;107(5):749-62.

³⁵Eichenfield, Lawrence F., et al. “Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis.” Journal of the American Academy of Dermatology 70.2 (2014): 338-351

³⁶National Institutes of Health (NIH). Health Topics: Atopic Dermatitis. Available at: https://www.niams.nih.gov/health-topics/atopic-dermatitis. Last accessed June 2021.

³⁷Nordin S, Hedén Blomqvist E, Olsson P, Stjärne P, Ehnhage A, NAF2S2 Study Group. Effects of smell loss on daily life and adopted coping strategies in patients with nasal polyposis with asthma. Acta oto-laryngologica. 2011 Aug 1;131(8):826-32.

³⁸Wang R, Hirano I, Doerfler B, Zalewski A, Gonsalves N, Taft T. Assessing adherence and barriers to long-term elimination diet therapy in adults with eosinophilic esophagitis. Digestive diseases and sciences. 2018 Jul;63(7):1756-62.

³⁹Prussin C, Lee J, Foster B. Eosinophilic gastrointestinal disease and peanut allergy are alternatively associated with IL-5+ and IL-5- TH2 responses. Journal of allergy and clinical immunology. 2009 Dec 1;124(6):1326-32.

⁴⁰Mayo Clinic. Peanut Allergy. Available at: https://www.mayoclinic.org/diseases-conditions/peanut-allergy/symptoms-causes/syc-20376175. Accessed June 2021.

⁴¹Seys, Sven F., et al. “Cluster analysis of sputum cytokine-high profiles reveals diversity in T (h) 2-high asthma patients.” Respiratory research 18.1 (2017): 1-10.

⁴²Jackson DJ, Aljamil N, Roxas C, et al. The ‘T2-low’ asthma phenotype: could it just be T2-high asthma treated with corticosteroids? Thorax. 2018;73(suppl 4):A124-A125

⁴³M. Suárez-Fariñas, N. Dhingra and J. Gittler, “Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis,” Journal of Allergy and Clinical Immunology, vol. 132, no. 2, pp. 361-70, 2013.

⁴⁴M. Chaaban, E. M. Walsh and B. A. Woodworth, “Epidemiology and differential diagnosis of nasal polyps.,” American Journal of Rhinology & Allergy, vol. 27, no. 6, pp. 473-478, 2013.

⁴⁵Chehade M, et al. Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research. J Allergy Clin Immunol Pract. 2018;6(5):1534-1544.

⁴⁶Pereira MP, et al. Chronic nodular prurigo: clinical profile and burden. A European cross‐sectional study. [published online ahead of print, 2020 Feb 20]. J Eur Acad Dermatol Venereol. 2020.

⁴⁷Zeidler C, et al. Chronic prurigo of nodular type: a review. Acta Derm Venereol. 2018;98(2):173-179.

⁴⁸Pereira MP, et al. European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology

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As part of its day-to-day operation, SANOFI provides access to a variety of tools and resources which are destined to provide information to all the individuals with whom it has business interactions with (patients and their relatives, participants to clinical trials, healthcare professionals, users of products and services, workers, etc.) regarding its activities.

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For the purposes of this Website Privacy Policy, Personal Data is any information relating to an identified or identifiable natural person, for all data processing carried out in the framework of its business and activities

To make things clear, it is any information that relates to an individual. Such Personal Data can take the form of:
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Etc.

In this respect, the notion of “processing” designates any action that is undertaken on your Personal Data such as, for instance:

Collection;
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Analysis;
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Etc.

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In addition, this website embeds poll functionality which asks survey questions regarding health conditions. The responses to the survey questions are collected anonymously and aggregated with other responses in order to show collective results. The poll is multiple-choice with no option for free text.

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Any processing of Personal Data must be implemented for a defined purpose. In this respect, the collection and processing of Personal Data on this Website is conducted for the following purposes:

To personalize your browsing experience: when using our services; ensure that our services are presented in the way the best suits you; understand your professional and personal interests in our content, product and services or other content and adapt our content to your needs and preferences; present you products and offers tailored to you.
To improve our products and services: identify usage trends and develop new products and services; understand how you and your device interacts with our services; track and respond to safety concerns; determine the effectiveness of our promotional campaigns, conduct surveys.

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your prior CONSENT: where you have clearly expressed your approval of SANOFI’s processing of your Personal Data. In practice, this will generally mean that SANOFI will ask you to sign a document, or to fill-in an online “opt-in” form or to follow any relevant procedure to allow you to be fully informed and then either clearly accept or refuse the envisaged Personal DATA processing. By navigating this Website and, if relevant, consenting to the processing of your Personal Data using cookies (as per our cookies policy).
A contractual relationship between you and SANOFI: in such case, the processing of your Personal DATA is generally necessary to the execution or the performance of the contract; this means that if you do not wish SANOFI to process your Personal Data in that context, SANOFI may or will be obliged to refuse to enter into such contract with you or will not be able to provide the products or services covered in this contract.
The “legitimate interest” of SANOFI in the sense of applicable data protection law. In such a case, SANOFI shall consider your fundamental rights and interests in determining whether the processing is legitimate and lawful.

HOW LONG IS THE PERSONAL DATA COLLECTED ON THIS WEBSITE RETAINED?
The Personal Data collected on this Website will be retained for the following periods, depending on the categories of Personal Data processed

Connection data: Session duration
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SANOFI may transfer your Personal Data both internally (i.e. to other SANOFI entities) and/or externally to third party service providers for the purposes outlined above.
Where such internal or external transfer of Personal Data implies the transfer of your Personal Data to a country providing a lower level of protection to Personal Data than generally afforded in your jurisdiction, SANOFI will ensure that a sufficient level of protection is provided to your Personal Data by implementing adequate safeguards such as the European Standard Contractual Clauses, the SANOFI Binding Corporate Rules or asking for your prior explicit consent.

YOUR RIGHTS: SANOFI WILL ENSURE THAT YOU CAN EXERCISE YOUR RIGHTS PERTAINING TO YOUR PERSONAL DATA
You can exercise your rights as provided by applicable data protection laws.
To that end, SANOFI informs you that you are entitled:

to have access upon simple request to your Personal Data- in which case you may receive a copy of such data (if requested), unless such data is made directly available to you, for instance within your personal account;
to obtain a rectification of your Personal Data should your Personal Data be inaccurate, incomplete or obsolete;
to obtain the deletion of your Personal Data in the situations set forth by applicable data protection law (‘right to be forgotten’);
to withdraw your consent to the processing of Persona Data processing without affecting the lawfulness of processing, where your Personal Data has been collected and processed on the basis of your consent;
to object to the processing of your Personal Data, where your Personal Data has been collected and processed on the basis of legitimate interests of SANOFI, in which case you will need to justify your request by explaining to us your particular situation;
to request a limitation of the processing of Personal Data processing in the situations set forth by applicable data protection law;
to receive your Personal Data for transmission from SANOFI to a third-party or to have your Personal Data directly transferred by SANOFI to the third-party of your choice, where technically feasible (data portability right allowed only where the processing is based on your consent)

if you would like to exercise any of these rights, please contact us as described in the “How to Contact Us” section below and we will take necessary steps to respond as soon as possible.

You may also file a complaint before a competent data protection authority regarding the processing of your Personal Data. While we suggest that you contact us beforehand, if you wish to exercise this right, you shoud contact directly the competent data protection authority.

HOW TO CONTACT US
SANOFI welcomes any questions or comments you may have regarding this Website Privacy Policy or its implementation. You can send any request pertaining to SANOFI’s use of your Personal Data to our Data Protection Officer at the following email address: privacy-office-global@sanofi.com.

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